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Article

Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies.

Blood - 9 Apr 2009

Busque Lambert, Paquette Yves, Provost Sylvie, Roy Denis-Claude, Levine Ross L, Mollica Luigina, Gilliland D Gary

Abstract excerpt

Nonrandom X-chromosome inactivation (XCI), also known as skewing, has been documented in the blood cells of a significant proportion of normal aging women by the use of methylation-based assays at the polymorphic human androgen receptor locus (HUMARA). Recent data obtained with a new transcription-based XCI determination method, termed suppressive polymerase chain reaction (PCR), has shed controversy over the...

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Share to Aging
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Dosage Compensation, Genetic

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Source

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Identifiers

PMID: 19202126
DOI: 10.1182/blood-2008-12-195677
PMCID: PMC4729536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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