Article
A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation.
Biology of sex differences - 17 Jul 2020
Zhang Xinzhu, Li Yuhong, Ma Lei, Zhang Guofu, Liu Min, Wang Chuanyue, Zheng Yi, Li Rena
Abstract excerpt
BACKGROUND: X chromosome inactivation (XCI) is the mechanism by which the X-linked gene dosage is adjusted between the sexes. Evidence shows that many sex-specific diseases have their basis in X chromosome biology. While female schizophrenia patients often have a delayed age of disease onset and clinical phenotypes that are different from those of males, it is unknown whether the sex differences in schizophrenia...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.