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Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women

22 Feb 2021

Abstract excerpt

Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Skewed X-chromosome inactivation was here measured longitudinally by the HUMARA assay in 67 septuagenarian and octogenarian women assessed at 2 time points, 10 years apart, and...

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Share to Birth, Development, and Health
Share to Epigenetics and DNA Methylation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

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PMID: 33619309
DOI: 10.1038/s41598-021-83702-2

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