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Article

CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2012

Wang Danxin, Sun Xiaochun, Gong Yan, Gawronski Brian E, Langaee Taimour Y, Shahin Mohamed Hossam A, Khalifa Sherief I, Johnson Julie A

Abstract excerpt

CYP2C9 is involved in metabolism of nearly 25% of clinically used drugs. Coding region polymorphisms CYP2C9*2 and *3 contribute to interperson variability in drug dosage and clinical outcomes, whereas the role of a regulatory polymorphism remains uncertain. Measuring allelic RNA expression in 87 human liver samples, combined with genotyping, sequencing, and reporter gene assays, we identified a promoter variable...

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Identifiers

PMID: 22289258
DOI: 10.1124/dmd.111.044255
PMCID: PMC3336799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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