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Article

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.

The pharmacogenomics journal - 1 Aug 2011

Wang D, Guo Y, Wrighton S A, Cooke G E, Sadee W

Abstract excerpt

Cytochrome P450 3A4 (CYP3A4) metabolizes ∼50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of genetic factors remains uncertain. In this study, we measured allelic CYP3A4 heteronuclear RNA (hnRNA) and mRNA expression in 76 human liver samples heterozygous for at least one of eight marker SNPs and found marked allelic expression imbalance...

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Identifiers

PMID: 20386561
DOI: 10.1038/tpj.2010.28
PMCID: PMC3248744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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