Article
Novel single nucleotide polymorphism in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans.
Translational research : the journal of laboratory and clinical medicine - 1 Jun 2015
Hernandez Wenndy, Aquino-Michaels Keston, Drozda Katarzyna, Patel Shitalban, Jeong Young, Takahashi Harumi, Cavallari Larisa H, Perera Minoli A
Abstract excerpt
Warfarin is a widely used anticoagulant whose active S-enantiomer is primarily metabolized by the CYP2C9 enzyme. The CYP2C9*2 and CYP2C9*3 alleles are associated with lower warfarin dose requirement and decreased enzyme activity. In contrast, we previously identified a novel single-nucleotide polymorphism (SNP) (rs7089580A > T) in CYP2C9 that is associated with higher warfarin dose requirement in African...
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