Article
The effect of genetic variants in the transcription factor TSPYL family on the CYP3A4 mediated cyclosporine metabolism in kidney transplant patients.
Clinical and translational science - 1 Feb 2024
Zhai Qinglian, Moes Dirk Jan A R, van Gelder Teun, van der Lee Maaike, Sanders Jan-Stephan, Bemelman Frederike J, de Fijter Johan W, Klein Kathrin, Schwab Matthias, Swen Jesse J
Abstract excerpt
CYP3A4 activity shows considerable interindividual variability. Although studies indicate 60%-80% is heritable, common single nucleotide variants (SNVs) in CYP3A4 together only explain ~10%. Transcriptional factors, such as the testis-specific Y-encoded-like proteins (TSPYLs) family, have been reported to regulate the expression of CYP enzymes including CYP3A4 in vitro. Here, we investigated the effect of genetic...
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