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Article

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing.

Pharmacogenetics and genomics - 1 Jan 2016

Wang Danxin, Sadee Wolfgang

Abstract excerpt

Cytochrome P450 3A4 (CYP3A4) metabolizes 30-50% of clinically used drugs. Large interperson variability in CYP3A4 activity affects response to CYP3A4 substrate drugs. We had demonstrated that an intronic single nucleotide polymorphism rs35599367 (CYP3A4*22, located in intron 6) reduces mRNA/protein expression; however, the underlying mechanism remained unknown. Here we show that CYP3A4*22 is associated with a...

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Identifiers

PMID: 26488616
DOI: 10.1097/FPC.0000000000000183
PMCID: PMC4674354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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