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Article

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

The Journal of pharmacology and experimental therapeutics - 1 Mar 2010

Lamba Vishal, Panetta John C, Strom Stephen, Schuetz Erin G

Abstract excerpt

Variability in hepatic CYP3A4 cannot be explained by common CYP3A4 coding variants. We previously identified polymorphisms in pregnane X receptor (PXR) and ATP-binding cassette subfamily B member 1 (ABCB1) associated with CYP3A4 mRNA levels in small cohorts of human livers. However, the relative contributions of these genetic variations or of polymorphisms in other CYP3A4 regulators to variable CYP3A4 expression...

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Share to Cytochrome P-450 CYP3A
Share to Hepatocyte Nuclear Factor 3-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linear Models

Share to Pregnane X Receptor

Share to Promoter Regions, Genetic

Share to Receptors, Steroid

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Source

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Identifiers

PMID: 19934400
DOI: 10.1124/jpet.109.160804
PMCID: PMC2835441

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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