SORL1 genetic variants and cerebrospinal fluid  biomarkers of Alzheimer’s disease.

doi:10.1007/s00406-012-0295-x

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Article

SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer’s disease.

European archives of psychiatry and clinical neuroscience - 1 Sept 2012

Guo Liang-Hao, Westerteicher Christine, Wang Xin-Hui, Kratzer Martina, Tsolakidou Amalia, Jiang Meizi, Grimmer Timo, Laws Simon M, Alexopoulos Panagiotis, Bujo Hideaki, Kurz Alexander, Perneczky Robert

Abstract excerpt

The neuronal sortilin-related receptor with A-type repeats (SORL1, also called LR11 or sorLA) is involved in amyloidogenesis, and the SORL1 gene is a major risk factor for Alzheimer’s disease (AD). We investigated AD-related CSF biomarkers for associations with SORL1 genetic variants in 105 German patients with mild cognitive impairment (MCI) and AD. The homozygous CC-allele of single nucleotide polymorphism...

Topics

Aged
Alzheimer Disease
Amyloid beta-Peptides
Biomarkers
Case-Control Studies
Cognitive Dysfunction
Female
Genetic Predisposition to Disease
Humans
LDL-Receptor Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Membrane Transport Proteins

Middle Aged

Peptide Fragments

Polymorphism, Single Nucleotide

tau Proteins

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Open in PubMed

Identifiers

PMID: 22286501
DOI: 10.1007/s00406-012-0295-x

Genes

SORL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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