Article
Sequence variation in SORL1 and dementia risk in Swedes.
Neurogenetics - 1 Feb 2010
Reynolds Chandra A, Hong Mun-Gwan, Eriksson Ulrika K, Blennow Kaj, Johansson Boo, Malmberg Bo, Berg Stig, Gatz Margaret, Pedersen Nancy L, Bennet Anna M, Prince Jonathan A
Abstract excerpt
The gene encoding the neuronal sortilin-related receptor SORL1 has been claimed to be associated with Alzheimer's disease (AD) by independent groups and across various human populations. We evaluated six genetic markers in SORL1 in a sample of 1,558 Swedish dementia cases (including 1,270 AD cases) and 2,179 controls. For both single-marker-based and haplotype-based analyses, we found no strong support for SORL1...
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