Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

doi:10.1038/ng.1073

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Article

Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

Nature genetics - 29 Jan 2012

Kettunen Johannes, Tukiainen Taru, Sarin Antti-Pekka, Ortega-Alonso Alfredo, Tikkanen Emmi, Lyytikäinen Leo-Pekka, Kangas Antti J, Soininen Pasi, Würtz Peter, Silander Kaisa, Dick Danielle M, Rose Richard J, Savolainen Markku J, Viikari Jorma, Kähönen Mika, Lehtimäki Terho, Pietiläinen Kirsi H, Inouye Michael, McCarthy Mark I, Jula Antti, Eriksson Johan, Raitakari Olli T, Salomaa Veikko, Kaprio Jaakko, Järvelin Marjo-Riitta, Peltonen Leena, Perola Markus, Freimer Nelson B, Ala-Korpela Mika, Palotie Aarno, Ripatti Samuli

Abstract excerpt

Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2.31 × 10(-10)) at 31 loci, including 11 for which there have not been previous reports...

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PMID: 22286219
DOI: 10.1038/ng.1073
PMCID: PMC3605033

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