Article
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.
Nature communications - 28 Mar 2022
Yin Xianyong, Chan Lap Sum, Bose Debraj, Jackson Anne U, VandeHaar Peter, Locke Adam E, Fuchsberger Christian, Stringham Heather M, Welch Ryan, Yu Ketian, Fernandes Silva Lilian, Service Susan K, Zhang Daiwei, Hector Emily C, Young Erica, Ganel Liron, Das Indraniel, Abel Haley, Erdos Michael R, Bonnycastle Lori L, Kuusisto Johanna, Stitziel Nathan O, Hall Ira M, Wagner Gregory R, Kang Jian, Morrison Jean, Burant Charles F, Collins Francis S, Ripatti Samuli, Palotie Aarno, Freimer Nelson B, Mohlke Karen L, Scott Laura J, Wen Xiaoquan, Fauman Eric B, Laakso Markku, Boehnke Michael
Abstract excerpt
Few studies have explored the impact of rare variants (minor allele frequency < 1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish population provides an ideal opportunity for such explorations, given the multiple bottlenecks and expansions that have shaped its history, and the enrichment for many otherwise rare alleles that has resulted. Here, we report genetic associations...
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