Article
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
Nature communications - 23 Mar 2016
Kettunen Johannes, Demirkan Ayşe, Würtz Peter, Draisma Harmen H M, Haller Toomas, Rawal Rajesh, Vaarhorst Anika, Kangas Antti J, Lyytikäinen Leo-Pekka, Pirinen Matti, Pool René, Sarin Antti-Pekka, Soininen Pasi, Tukiainen Taru, Wang Qin, Tiainen Mika, Tynkkynen Tuulia, Amin Najaf, Zeller Tanja, Beekman Marian, Deelen Joris, van Dijk Ko Willems, Esko Tõnu, Hottenga Jouke-Jan, van Leeuwen Elisabeth M, Lehtimäki Terho, Mihailov Evelin, Rose Richard J, de Craen Anton J M, Gieger Christian, Kähönen Mika, Perola Markus, Blankenberg Stefan, Savolainen Markku J, Verhoeven Aswin, Viikari Jorma, Willemsen Gonneke, Boomsma Dorret I, van Duijn Cornelia M, Eriksson Johan, Jula Antti, Järvelin Marjo-Riitta, Kaprio Jaakko, Metspalu Andres, Raitakari Olli, Salomaa Veikko, Slagboom P Eline, Waldenberger Melanie, Ripatti Samuli, Ala-Korpela Mika
Abstract excerpt
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide association study of genetic influences on...
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