Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.

doi:10.1093/hmg/ddr581

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Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.

Human molecular genetics - 15 Mar 2012

Tukiainen Taru, Kettunen Johannes, Kangas Antti J, Lyytikäinen Leo-Pekka, Soininen Pasi, Sarin Antti-Pekka, Tikkanen Emmi, O'Reilly Paul F, Savolainen Markku J, Kaski Kimmo, Pouta Anneli, Jula Antti, Lehtimäki Terho, Kähönen Mika, Viikari Jorma, Taskinen Marja-Riitta, Jauhiainen Matti, Eriksson Johan G, Raitakari Olli, Salomaa Veikko, Järvelin Marjo-Riitta, Perola Markus, Palotie Aarno, Ala-Korpela Mika, Ripatti Samuli

Abstract excerpt

Almost 100 genetic loci are known to affect serum cholesterol and triglyceride levels. For many of these loci, the biological function and causal variants remain unknown. We performed an association analysis of the reported 95 lipid loci against 216 metabolite measures, including 95 measurements on lipids and lipoprotein subclasses, obtained via serum nuclear magnetic resonance metabolomics and four enzymatic...

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PMID: 22156771
DOI: 10.1093/hmg/ddr581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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