Article
Genome-wide characterization of circulating metabolic biomarkers.
Nature - 1 Apr 2024
Karjalainen Minna K, Karthikeyan Savita, Oliver-Williams Clare, Sliz Eeva, Allara Elias, Fung Wing Tung, Surendran Praveen, Zhang Weihua, Jousilahti Pekka, Kristiansson Kati, Salomaa Veikko, Goodwin Matt, Hughes David A, Boehnke Michael, Fernandes Silva Lilian, Yin Xianyong, Mahajan Anubha, Neville Matt J, van Zuydam Natalie R, de Mutsert Renée, Li-Gao Ruifang, Mook-Kanamori Dennis O, Demirkan Ayse, Liu Jun, Noordam Raymond, Trompet Stella, Chen Zhengming, Kartsonaki Christiana, Li Liming, Lin Kuang, Hagenbeek Fiona A, Hottenga Jouke Jan, Pool René, Ikram M Arfan, van Meurs Joyce, Haller Toomas, Milaneschi Yuri, Kähönen Mika, Mishra Pashupati P, Joshi Peter K, Macdonald-Dunlop Erin, Mangino Massimo, Zierer Jonas, Acar Ilhan E, Hoyng Carel B, Lechanteur Yara T E, Franke Lude, Kurilshikov Alexander, Zhernakova Alexandra, Beekman Marian, van den Akker Erik B, Kolcic Ivana, Polasek Ozren, Rudan Igor, Gieger Christian, Waldenberger Melanie, Asselbergs Folkert W, Hayward Caroline, Fu Jingyuan, den Hollander Anneke I, Menni Cristina, Spector Tim D, Wilson James F, Lehtimäki Terho, Raitakari Olli T, Penninx Brenda W J H, Esko Tonu, Walters Robin G, Jukema J Wouter, Sattar Naveed, Ghanbari Mohsen, Willems van Dijk Ko, Karpe Fredrik, McCarthy Mark I, Laakso Markku, Järvelin Marjo-Riitta, Timpson Nicholas J, Perola Markus, Kooner Jaspal S, Chambers John C, van Duijn Cornelia, Slagboom P Eline, Boomsma Dorret I, Danesh John, Ala-Korpela Mika, Butterworth Adam S, Kettunen Johannes
Abstract excerpt
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11. Here we present a genome-wide association study for 233 circulating metabolic traits...
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