Article
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
PLoS genetics - 1 Nov 2008
Gieger Christian, Geistlinger Ludwig, Altmaier Elisabeth, Hrabé de Angelis Martin, Kronenberg Florian, Meitinger Thomas, Mewes Hans-Werner, Wichmann H-Erich, Weinberger Klaus M, Adamski Jerzy, Illig Thomas, Suhre Karsten
Abstract excerpt
The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the physiological state of the human body. Genetic variants that associate with changes in the homeostasis of key lipids, carbohydrates, or amino acids are not only expected to display much larger effect sizes due to their direct...
Topics
- Blood Proteins
- Delta-5 Fatty Acid Desaturase
- Fatty Acid Desaturases
- Genetics
- Genome, Human
- Genome-Wide Association Study
- Humans
- Male
- Metabolomics
- Organic Chemicals