Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High copies of SUM1 enhance the stability of wild-type microtubules against adverse conditions in Saccharomyces cerevisiae.

Biochemical and biophysical research communications - 17 Feb 2012

Haldar Subhash, Sarkar Sourav, Singh Vinay, Sinha Pratima

Abstract excerpt

The budding yeast transcriptional repressor Sum1p binds to several promoters and recruits Hst1p, an NAD(+)-dependent histone deacetylase, at these promoters with the help of another protein Rfm1p. Hst1p causes repression of transcription by histone deacetylation of chromatin at its target promoters. In an earlier work we have shown that about 13-fold increase in Sum1p levels, brought about by expressing SUM1 from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Dosage
Share to Microtubules

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Folding

Share to Repressor Proteins

Share to Saccharomyces cerevisiae Proteins

Share to Stress, Physiological

Share to Suppression, Genetic

Share to Tubulin

Source

Identifiers

PMID: 22285862
DOI: 10.1016/j.bbrc.2012.01.059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High copies of SUM1 enhance the stability of wild-type microtubules against adverse conditions in Saccharomyces cerevisiae.PMID 22285862Read ↗

Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules.Semantic proximity Read ↗

Deletion of a single-copy tRNA affects microtubule function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dosage suppressors of a benomyl-dependent tubulin mutant: evidence for a link between microtubule stability and cellular metabolism.Semantic proximity Read ↗

The evolutionary conserved BER1 gene is involved in microtubule stability in yeast.Semantic proximity Read ↗

STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle.Semantic proximity Read ↗

An alpha-tubulin mutant destabilizes the heterodimer: phenotypic consequences and interactions with tubulin-binding proteins.Semantic proximity Read ↗

Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant.Semantic proximity Read ↗

Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast.Semantic proximity Read ↗

Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.Semantic proximity Read ↗

Evolutionary adaptation to hyperstable microtubules selectively targets tubulins and is empowered by the spindle assembly checkpoint.Semantic proximity Read ↗

Extragenic suppressors that rescue defects in the heat stress response of the budding yeast mutant tom1.Semantic proximity Read ↗

The essential yeast Tcp1 protein affects actin and microtubules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.