Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.

Cell cycle (Georgetown, Tex.) - 1 Nov 2008

Li Ju-mei, Tetzlaff Michael T, Elledge Stephen J

Abstract excerpt

The Dpb11 and Drc1/Sld2 proteins form a complex that is critical for the initiation of DNA replication. In this study we identify MSA1 as a high copy suppressor of a drc1-1 mutant. MSA1 overproduction can also suppress the temperature sensitivity of dpb11-1 and pol2-12 mutants. Reciprocally, msa1 deletion exacerbates the mutant phenotypes of both drc1/sld2 and dpb11 mutants and msa1 deletion alone results in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Suppressor

Share to Genome, Fungal

Share to S Phase

Share to Suppression, Genetic

Share to Temperature

Source

Identifiers

PMID: 18948746
DOI: 10.4161/cc.7.21.6932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.PMID 18948746Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p.Semantic proximity Read ↗

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.Semantic proximity Read ↗

The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.Semantic proximity Read ↗

Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.Semantic proximity Read ↗

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.Semantic proximity Read ↗

Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.Semantic proximity Read ↗

A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.Semantic proximity Read ↗

Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7.Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.