Article
Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules.
Genetics - 1 Jun 1994
Kirkpatrick D, Solomon F
Abstract excerpt
Microtubules in eukaryotic cells participate in a variety of nuclear and cytoplasmic structures, reflecting functional requirements and cell cycle position. We are studying the cellular regulation of microtubule assembly and organization in the yeast Saccharomyces cerevisiae. We screened for gene...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Cycle
- Cell Cycle Proteins
- Conserved Sequence
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genotype
- Guanine Nucleotide Exchange Factors
- Mammals
- Microtubules
- Molecular Sequence Data
- Multigene Family
- Mutation
- Nuclear Proteins