Article
Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant.
Molecular biology of the cell - 1 Sept 1995
Machin N A, Lee J M, Barnes G
Abstract excerpt
To better understand the dynamic regulation of microtubule structures in yeast, we studied a conditional-lethal beta-tubulin mutation tub2-150. This mutation is unique among the hundreds of tubulin mutations isolated in Saccharomyces cerevisiae in that it appears to cause an increase in the stability of microtubules. We report here that this allele is a mutation of threonine 238 to alanine, and that tub2-150...
Topics
- Alleles
- Amino Acid Sequence
- Anaphase
- Animals
- Benomyl
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Microtubules
- Molecular Sequence Data
- RNA-Binding Proteins