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Article

Evolutionary adaptation to hyperstable microtubules selectively targets tubulins and is empowered by the spindle assembly checkpoint.

Cell reports - 25 Feb 2025

Macaluso Francesca, Bos Tasia, Chiroli Elena, Bonaiuti Paolo, Apuan Jason C, Gross Fridolin, Pompei Simone, Rice Luke M, Ciliberto Andrea

Abstract excerpt

Microtubules are polymers required for chromosome segregation. Their drug-induced hyperstabilization impairs chromosome segregation and is an established anti-cancer therapy. How cells respond to microtubule hyperstabilization, however, is incompletely understood. To study this, we evolved budding yeast cells expressing a microtubule-hyperstabilizing tubulin mutant and isolated adapted strains. Aneuploidy of...

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Identifiers

PMID: 39955777
DOI: 10.1016/j.celrep.2025.115323
PMCID: PMC12581159

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