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Article

Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2012

Liao Hsin-Kai, Wang Ying, Noack Watt Kristin E, Wen Qin, Breitbach Justin, Kemmet Chelsy K, Clark Karl J, Ekker Stephen C, Essner Jeffrey J, McGrail Maura

Abstract excerpt

BACKGROUND: The single spanning transmembrane amyloid precursor protein (APP) and its proteolytic product, amyloid-beta (Ab) peptide, have been intensely studied due to their role in the pathogenesis of Alzheimer's disease. However, the biological role of the secreted ectodomain of APP, which is also generated by proteolytic cleavage, is less well understood. Here, we report Tol2 red fluorescent protein (RFP)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22275008
DOI: 10.1002/dvdy.23725
PMCID: PMC3448447

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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