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Article

Generation of conditional null alleles for APP and APLP2.

Genesis (New York, N.Y. : 2000) - 1 Mar 2010

Mallm Jan-Philipp, Tschäpe Jakob-Andreas, Hick Meike, Filippov Mikhail A, Müller Ulrike C

Abstract excerpt

Proteolytical cleavage of the beta-amyloid precursor protein (APP) generates beta-amyloid, which is deposited in the brains of patients suffering from Alzheimer's disease (AD). Despite the well-established key role of APP for AD pathogenesis, the physiological function of APP and its close homolo...

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Source

Identifiers

PMID: 20140888
DOI: 10.1002/dvg.20601

Genes

APP
APLP2
APLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20140888-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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