Article
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.
Genome research - 1 Apr 2012
Jiang Zhaoshi, Jhunjhunwala Suchit, Liu Jinfeng, Haverty Peter M, Kennemer Michael I, Guan Yinghui, Lee William, Carnevali Paolo, Stinson Jeremy, Johnson Stephanie, Diao Jingyu, Yeung Stacy, Jubb Adrian, Ye Weilan, Wu Thomas D, Kapadia Sharookh B, de Sauvage Frederic J, Gentleman Robert C, Stern Howard M, Seshagiri Somasekar, Pant Krishna P, Modrusan Zora, Ballinger Dennis G, Zhang Zemin
Abstract excerpt
Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). HBV integration into the host genome has been reported, but its scale, impact and contribution to HCC development is not clear. Here, we sequenced the tumor and nontumor genomes (>80× coverage) and transcriptomes of four HCC patients and identified 255 HBV integration sites. Increased sequencing to 240× coverage...
Topics
- Base Sequence
- Binding Sites
- Carcinoma, Hepatocellular
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genome, Human
- Hepatitis B