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Profiles of HBV DNA integration in humans with hepatitis B virus infection: Insights for antiviral treatment

17 Jun 2025

Abstract excerpt

Introduction We aimed to determine hepatitis B virus (HBV) integration profiles in the natural history of chronic HBV infection (CHB). Methods We delineated integration profiles from liver biopsies of 55 patients in different CHB phases (3 HBsAg-positive/HBeAg-positive infection; 13 HBsAg-positive/HBeAg-positive hepatitis; 7 HBsAg-positive/HBeAg-negative infection; 12 HBsAg-positive/HBeAg-negative hepatitis; 10...

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PMID: 40893931
DOI: 10.1016/j.jhepr.2025.101487

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