Article

Long read sequencing reveals sequential complex rearrangements driven by Hepatitis B virus integration

2021-12-09

Abstract excerpt

Integration of Hepatitis B virus (HBV) into human genome disrupts genetic structures and cellular functions. Here, we conducted multiplatform long read sequencing on two cell lines and five clinical samples of HBV-infected hepatocellular carcinomas (HCC). We resolved three types of viral integration-induced complex genome rearrangements (CGR) and proposed a model of ‘multi-hits and sequential-breaks’ to depict the...

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Literature Corpus work: 65191879-5ce1-5dbc-8633-308a506210ad
DOI: 10.1101/2021.12.09.471697

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