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Article

Oncogenic HBV variants and integration are present in hepatic and lymphoid cells derived from chronic HBV patients.

Cancer letters - 28 Jun 2020

Lau Keith Ck, Joshi Shivali S, Gao Shan, Giles Elizabeth, Swidinsky Ken, van Marle Guido, Bathe Oliver F, Urbanski Stefan J, Terrault Norah A, Burak Kelly W, Osiowy Carla, Coffin Carla S

Abstract excerpt

The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly driven by viral integration and specific oncogenic HBV variants. However, the biological significance of HBV genomes within lymphoid cells (i.e., peripheral blood mononuclear cells, PBMCs) is unclear. Here, we collected available plasma, PBMC, liver, and tumor from 52 chronic HBV (CHB) carriers: 32 with HCC, 19 without HCC, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32229190
DOI: 10.1016/j.canlet.2020.03.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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