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HBV integrations reshaping genomic structures promote hepatocellular carcinoma

23 Feb 2024

Abstract excerpt

Objective Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), mostly characterised by HBV integrations, is prevalent worldwide. Previous HBV studies mainly focused on a few hotspot integrations. However, the oncogenic role of the other HBV integrations remains unclear. This study aimed to elucidate HBV integration-induced tumourigenesis further. Design Here, we illuminated the genomic structures...

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PMID: 38395437
DOI: 10.1136/gutjnl-2023-330414

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