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Insights into Hepatitis B Virus DNA Integration-55 Years after Virus Discovery

1 Aug 2020

Abstract excerpt

Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health. HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is no cure. In cells infected by HBV, viral DNA can be integrated into the cellular genome. HBV DNA integration is a complicated process during the HBV life cycle. Although HBV integration normally results in replication-incompetent...

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PMID: 34557710
DOI: 10.1016/j.xinn.2020.100034

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