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Article

Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma

9 Feb 2021

Abstract excerpt

Objective Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC) worldwide. HBV directly drives carcinogenesis through integrations in the human genome. This study aimed to precisely characterise HBV integrations, in relation with viral and host genomics and clinical features. Design A novel pipeline was set up to perform viral capture on tumours and non-tumour liver tissues from a French...

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Identifiers

PMID: 33563643
DOI: 10.1136/gutjnl-2020-323153

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