Article
Assessing genuine parents-offspring trios for genetic association studies.
Human heredity - 1 Jan 2009
Teo Yik Y, Fry Andrew E, Sanjoaquin Miguel A, Pederson Bonnie, Small Kerrin S, Rockett Kirk A, Kwiatkowski Dominic P, Clark Taane G
Abstract excerpt
OBJECTIVES: Family-based association tests such as the transmission disequilibrium test (TDT) are dependent on the successful ascertainment of true nuclear family trios. Relationship misspecification inevitably occurs in a proportion of trios collected for genotyping which undetected can lead to a loss of power and increased Type I error due to biases in over-transmission of common alleles. Here, we introduce a...
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