Article
Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps.
Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2012
Yurgelun Matthew B, Goel Ajay, Hornick Jason L, Sen Ananda, Turgeon Danielle Kim, Ruffin Mack T, Marcon Norman E, Baron John A, Bresalier Robert S, Syngal Sapna, Brenner Dean E, Boland C Richard, Stoffel Elena M
Abstract excerpt
Colorectal cancers associated with Lynch syndrome are characterized by deficient DNA mismatch repair (MMR) function. Our aim was to evaluate the prevalence of microsatellite instability (MSI) and loss of MMR protein expression in Lynch syndrome-associated polyps. Sixty-two colorectal polyps--37 adenomatous polyps, 23 hyperplastic polyps, and 2 sessile serrated polyps (SSP)--from 34 subjects with germline MMR gene...
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