Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry.

doi:10.1038/modpathol.2011.209

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Article

Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2012

Walsh Michael D, Buchanan Daniel D, Pearson Sally-Ann, Clendenning Mark, Jenkins Mark A, Win Aung Ko, Walters Rhiannon J, Spring Kevin J, Nagler Belinda, Pavluk Erika, Arnold Sven T, Goldblatt Jack, George Jill, Suthers Graeme K, Phillips Kerry, Hopper John L, Jass Jeremy R, Baron John A, Ahnen Dennis J, Thibodeau Stephen N, Lindor Noralane, Parry Susan, Walker Neal I, Rosty Christophe, Young Joanne P

Abstract excerpt

Debate continues as to the usefulness of assessing adenomas for loss of mismatch repair protein expression to identify individuals with suspected Lynch syndrome. We tested 109 polyps from 69 proven mutation carriers (35 females and 34 males) belonging to 49 Lynch syndrome families. All polyps were tested by immunohistochemistry for four mismatch repair proteins MLH1, MSH2, MSH6 and PMS2. Detailed pathology review...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22322191
DOI: 10.1038/modpathol.2011.209
PMCID: PMC3477239

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

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