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Article

Hyperplastic polyps in hereditary nonpolyposis colorectal cancer.

The American journal of gastroenterology - 1 Oct 2003

Rijcken Fleur E M, van der Sluis Tineke, Hollema Harry, Kleibeuker Jan H

Abstract excerpt

OBJECTIVES: Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, in particular hMLH1, hMSH2, and hMSH6. Dysfunction of MMR genes leads to loss of MMR protein expression and to microsatellite instability (MSI). MSI is also detected in 10-20% of sporadic colorectal cancers. Hyperplastic polyps (HP) may serve as precursor for these...

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Source

Identifiers

PMID: 14572584
DOI: 10.1111/j.1572-0241.2003.07629.x

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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