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Article

Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study.

The Lancet. Oncology - 1 Jun 2012

Kloor Matthias, Huth Cathrin, Voigt Anita Y, Benner Axel, Schirmacher Peter, von Knebel Doeberitz Magnus, Bläker Hendrik

Abstract excerpt

BACKGROUND: Lynch syndrome is an inherited tumour predisposition syndrome caused by germline mutations of DNA mismatch repair (MMR) genes. Mutation carriers have a high risk of developing colorectal cancer, but do not present with polyposis, a typical feature of other colorectal cancer syndromes such as familial adenomatous polyposis, in which polyposis reflects the high frequency of biallelic APC gene...

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Source

Identifiers

PMID: 22552011
DOI: 10.1016/S1470-2045(12)70109-2

Genes

APC
EPCAM
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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