Article
Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.
International journal of colorectal disease - 1 Oct 2006
Müller Annegret, Beckmann Carmen, Westphal Gabriela, Bocker Edmonston Tina, Friedrichs Nicolaus, Dietmaier Wolfgang, Brasch Frank E, Kloor Matthias, Poremba Christoph, Keller Gisela, Aust Daniela E, Fass Jürgen, Büttner Reinhard, Becker Heinz, Rüschoff Josef
Abstract excerpt
In hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, more than 90% of the carcinomas show microsatellite instability (MSI) due to a loss of mismatch repair (MMR) function. Although adenomas are very common in HNPCC and demonstrate an accelerated adenoma-carcinoma sequence, data about the prevalence and development of MSI in these early neoplastic lesions are lacking. To determine whether MSI and loss of...
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