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Article

Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine

3 Mar 2003

Abstract excerpt

BACKGROUND: Carcinomas of the small intestine are rare, but the risk is greatly increased in patients with hereditary nonpolyposis colorectal cancer (HNPCC) due to an inherited mismatch repair (MMR) gene mutation, most commonly affecting the genes MLH1 or MSH2. Defective MMR is characterized by microsatellite instability (MSI) and loss of MMR protein expression in the tumor tissue. However, a subset of several...

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PMID: 12627520
DOI: 10.1002/cncr.11197

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