DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer.

doi:10.1136/gut.47.1.37

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Article

DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer.

Gut - 1 Jul 2000

Iino H, Simms L, Young J, Arnold J, Winship I M, Webb S I, Furlong K L, Leggett B, Jass J R

Abstract excerpt

BACKGROUND AND AIM: Hereditary non-polyposis colorectal cancer (HNPCC), as its name implies, is associated with few adenomas, and the early evolution of colorectal neoplasia is poorly understood. In this study our aim was to clarify the genetic profiles of benign polyps in subjects with HNPCC using a combined molecular and immunohistochemical approach. METHODS: Thirty adenomas and 17 hyperplastic polyps were...

Topics

Adenoma
Adult
Colon
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA, Neoplasm
Female
Humans
Hyperplasia
Male
Microsatellite Repeats
Middle Aged
Mutation
Precancerous Conditions

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PMID: 10861262
DOI: 10.1136/gut.47.1.37
PMCID: PMC1727981

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