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Article

Sporadic microsatellite instability-high colon cancers rarely display immunohistochemical evidence of Wnt signaling activation.

The American journal of surgical pathology - 1 Mar 2015

Panarelli Nicole C, Vaughn Cecily P, Samowitz Wade S, Yantiss Rhonda K

Abstract excerpt

Most sporadic colonic adenocarcinomas are microsatellite stable (MSS) and arise from conventional adenomas by dysregulation of the APC/β-catenin/Wnt signaling pathway. Sporadic adenocarcinomas with a high degree of microsatellite instability (MSI) likely arise from sessile serrated polyps through the serrated neoplastic pathway. These polyps contain BRAF mutations and are prone to epigenetic methylation that...

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Source

Identifiers

PMID: 25602793
DOI: 10.1097/PAS.0000000000000380

Genes

BRAF
MLH1
APC
PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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