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Article

Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients.

Journal of Crohn's & colitis - 1 Feb 2012

Brinar Marko, Vermeire Séverine, Cleynen Isabelle, Lemmens Bart, Sagaert Xavier, Henckaerts Liesbet, Van Assche Gert, Geboes Karel, Rutgeerts Paul, De Hertogh Gert

Abstract excerpt

BACKGROUND AND AIMS: Granulomas are a characteristic microscopic finding in Crohn's disease. Their clinical significance is controversial and their pathogenesis is unknown, but impaired processing of bacterial components has been suggested. Autophagy is a fundamental process involved in the elimination of intracellular bacteria. Genetic variants in autophagy genes IRGM and ATG16L1 have been associated with...

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Source

Identifiers

PMID: 22261526
DOI: 10.1016/j.crohns.2011.06.008

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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