Article
Granulomas in Crohn's disease: are newly discovered genetic variants involved?
Journal of Crohn's & colitis - 1 Oct 2010
Mazor Yoav, Karban Amir, Nesher Shula, Weiss Batia, Leshinsky-Silver Esther, Levine Arie, Eliakim Rami
Abstract excerpt
BACKGROUND: Non-caseating granulomas exist in a substantial portion of patients with Crohn's disease (CD). Several single nucleotide polymorphisms (SNPs) have been identified as a having strong association with CD, including SNPs within the autophagy related 4 homolog A (ATG4A) gene and the neutrophil cytosolic factor 4 (NCF4) gene. We hypothesized a possible association between the presence of granulomas in CD...
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