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Article

Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.

The Journal of biological chemistry - 30 Dec 2016

Davydova Natalia, Harris Nicole C, Roufail Sally, Paquet-Fifield Sophie, Ishaq Musarat, Streltsov Victor A, Williams Steven P, Karnezis Tara, Stacker Steven A, Achen Marc G

Abstract excerpt

VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics. VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct signaling...

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Source

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Identifiers

PMID: 27852824
DOI: 10.1074/jbc.M116.736801
PMCID: PMC5207153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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