Article
Novel vascular endothelial growth factor D variants with increased biological activity.
The Journal of biological chemistry - 5 Jun 2009
Toivanen Pyry I, Nieminen Tiina, Viitanen Lenita, Alitalo Annamari, Roschier Miia, Jauhiainen Suvi, Markkanen Johanna E, Laitinen Olli H, Airenne Tomi T, Salminen Tiina A, Johnson Mark S, Airenne Kari J, Ylä-Herttuala Seppo
Abstract excerpt
Members of the vascular endothelial growth factor (VEGF) family play a pivotal role in angiogenesis and lymphangiogenesis. They are potential therapeutics to induce blood vessel formation in myocardium and skeletal muscle, when normal blood flow is compromised. Most members of the VEGF/platelet derived growth factor protein superfamily exist as covalently bound antiparallel dimers. However, the mature form of...
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