Article
The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407.
The Journal of biological chemistry - 12 Nov 2010
Anthony Colin S, Corradi Hazel R, Schwager Sylva L U, Redelinghuys Pierre, Georgiadis Dimitris, Dive Vincent, Acharya K Ravi, Sturrock Edward D
Abstract excerpt
Angiotensin-I-converting enzyme (ACE) plays a critical role in the regulation of blood pressure through its central role in the renin-angiotensin and kallikrein-kinin systems. ACE contains two domains, the N and C domains, both of which are heavily glycosylated. Structural studies of ACE have been fraught with severe difficulties because of surface glycosylation of the protein. In order to investigate the role of...
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