Article

Computer-guided design of Z domain peptides with improved inhibition of VEGF

2024-11-30

Abstract excerpt

Computational protein design is becoming increasingly helpful in the development of new protein therapeutics with enhanced efficacy, specificity, and minimal side effects, for precise modulation of biological pathways. In vascular biology, the interaction between vascular endothelial growth factor A (VEGFA) and its receptors (VEGFR1-R3) is a pivotal process underlying blood vessel growth. Dysregulation of this pat...

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Literature Corpus work: 494fe9b2-1e59-51ae-95e8-898086e35ed7
DOI: 10.1101/2024.11.29.626075

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