Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2.

European journal of biochemistry - 1 Nov 2001

Kirkin V, Mazitschek R, Krishnan J, Steffen A, Waltenberger J, Pepper M S, Giannis A, Sleeman J P

Abstract excerpt

VEGF-C and VEGF-D are lymphangiogenic factors that bind to and activate VEGFR-3, a fms-like tyrosine kinase receptor whose expression is limited almost exclusively to lymphatic endothelium in the adult. Processed forms of VEGF-C and VEGF-D can also activate VEGFR-2, a key player in the regulation of angiogenesis. There is increasing evidence to show that these receptor-ligand interactions play a pivotal role in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Evaluation, Preclinical
Share to Endothelial Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indoles

Share to Naphthalenes

Share to Receptors, Growth Factor

Share to Receptors, Vascular Endothelial Growth Factor

Share to Vascular Endothelial Growth Factor C

Share to Vascular Endothelial Growth Factor Receptor-3

Source

Identifiers

PMID: 11683876
DOI: 10.1046/j.1432-1033.2001.02476.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2.PMID 11683876Read ↗

Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.Semantic proximity Read ↗

Molecular Characterization and Interaction between Human VEGF-D and VEGFR-3.Semantic proximity Read ↗

VEGF-mediated signal transduction in lymphatic endothelial cellsSemantic proximity Read ↗

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular developmentSemantic proximity Read ↗

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.Semantic proximity Read ↗

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.Semantic proximity Read ↗

A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular Endothelial Growth Factor to Its Kinase Domain ReceptorSemantic proximity Read ↗

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.Semantic proximity Read ↗

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis.Semantic proximity Read ↗

Identification of a novel anti-angiogenic regulatory sequence within the syndecan-3 extracellular core proteinSemantic proximity Read ↗

Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor.Semantic proximity Read ↗

Identification of the residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.