Article
Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2021
Moudra Alena, Niederlova Veronika, Novotny Jiri, Schmiedova Lucie, Kubovciak Jan, Matejkova Tereza, Drobek Ales, Pribikova Michaela, Stopkova Romana, Cizkova Dagmar, Neuwirth Ales, Michalik Juraj, Krizova Katerina, Hudcovic Tomas, Kolar Michal, Kozakova Hana, Kreisinger Jakub, Stopka Pavel, Stepanek Ondrej
Abstract excerpt
Ag-inexperienced memory-like T (AIMT) cells are functionally unique T cells, representing one of the two largest subsets of murine CD8+ T cells. However, differences between laboratory inbred strains, insufficient data from germ-free mice, a complete lack of data from feral mice, and an unclear relationship between AIMT cells formation during aging represent major barriers for better understanding of their...
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