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Article

Natural polyreactive IgA antibodies coat the intestinal microbiota

30 Sept 2017

Abstract excerpt

Large quantities of immunoglobulin A (IgA) are constitutively secreted by intestinal plasma cells to coat and contain the commensal microbiota, yet the specificity of these antibodies remains elusive. Here we profiled the reactivities of single murine IgA plasma cells by cloning and characterizing large numbers of monoclonal antibodies. IgAs were not specific to individual bacterial taxa but rather polyreactive,...

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Identifiers

PMID: 28971969
DOI: 10.1126/science.aan6619

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