Article
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.
Nature - 11 Dec 2011
Fritz Jörg H, Rojas Olga Lucia, Simard Nathalie, McCarthy Douglas D, Hapfelmeier Siegfried, Rubino Stephen, Robertson Susan J, Larijani Mani, Gosselin Jean, Ivanov Ivaylo I, Martin Alberto, Casellas Rafael, Philpott Dana J, Girardin Stephen E, McCoy Kathy D, Macpherson Andrew J, Paige Christopher J, Gommerman Jennifer L
Abstract excerpt
The largest mucosal surface in the body is in the gastrointestinal tract, a location that is heavily colonized by microbes that are normally harmless. A key mechanism required for maintaining a homeostatic balance between this microbial burden and the lymphocytes that densely populate the gastrointestinal tract is the production and transepithelial transport of poly-reactive IgA (ref. 1). Within the mucosal...
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